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DSRCT

About this blog

In January of 2006 my wife was diagnosed with Desmoplastic Small Blue Round Cell Tumor, also known as DSRCT, which is a rare and extremely aggressive form of cancer, usually with poor prognosis for survival.

After months of extensive chemotherapy, several operations, and more chemotherapy we thought she might have an actual chance of surviving. After two weeks of cautious hope our world was destroyed yet again when a scan showed that new tumors were growing in both lungs. There were no more medical means to cure her disease, and eventually she died on January 9th 2007.


To help others who are in a similar situation, my wife and I made this blog, where her entire treatment course is described in detail as a kind of diary. The blog also contains a short description of all the medication that has been part of the treatment.

Second round of chemotherapy

Medication Posted on 2006-12-15 14:40:19

After two operations where all visble tumors are removed from the right lung and the left thigh, Mette receives consolidating chemotherapy, from July 31rst to September 9th 2006.

Six rounds of CIVE were planned, but treatment stops after three series, as Mette is too weak and the sideeffects are alarming. The treatment is a “VIDE light”, where Doxorubicin is replaced with Caelyx because Doxorubicin effects heart- and kidney function when given in large quantities.

The doses are generally lower than during the VIDE treatment.

Day 1:
Caelyx 27 mg iv
Ifosfamide 4,3 mg iv
Vincristine 2 mg iv
Etoposide 216 mg iv

Day 2 and 3:
Caelyx 27 mg iv
Ifosfamide 4,3 mg iv
Etoposide 216 mg iv

Additionally: Mesna, Emend, SoluMedrol, Zofran, Vogalene.



Misc.

Medication Posted on 2006-12-15 14:39:46

After each round of chemotherapy Mette takes one syringe of Neupogen (300 μg) per day for 10-11 days after chemo, to help her immune system recover before the next round of chemo.
After the third round of CIVE the Neupogen dose is doubled, because of Mette’s weak immune system.

Painkillers:
Oxynorm 5 mg per day. Only taken in the first 2-3 weeks of hospitalisation.
OxyContin 40 mg per day. Taken in the first 2 months or so.



First round of chemotherapy

Medication Posted on 2006-12-15 14:27:33

Seven rounds of VIDE chemotherapy, February 8th to June 22th 2006, every round lasting approximately three weeks. Hospitalisation for 3-4 days at a time.

Day 1:
Vincristine 2 mg iv
Ifosfamide 5,4 g iv
Doxorubicin 36 mg iv
Etoposide 270 g iv
Mesna 1,8 g iv before and during the Ifosfamide treatment to lessen the sideeffects on bladder on kidneys.

Day 2+3:
Ifosfamide 5,4 g iv
Doxorubicin 36 mg iv
Etoposide 270 g iv
Mesna 1,8 g iv

To treat nausea: SoluMedrol, Vogalene, Zofran and Prednisolon.

After second round of chemo Mette is given Emend to treat nausea: 125 mg on the first day, 80 mg on second and third day, together with SoluMedrol: 160 mg on the first day, 80 mg on second and third day. Much better effect.



May 8th, 2006

Diary Posted on 2006-12-15 09:45:04

Fifth round of chemo. Normal dose of VIDE.
Mette’s response to the treatment is so good, that the doctors plan eight treatments instead of the initial six. They also conclude that if the tumors keep decreasing at the present rate, they may be able to entirely remove the tumors surgically. This is the first good news in months, and for the first time we begin to have a little hope…



April 18th, 2006

Diary Posted on 2006-12-15 09:38:05

Fourth round of chemo. No fevers or anything in the previous 2-3 weeks.
Bloodtransfusions.
The effect of the Neupogen is evident, as her immune system is quite good this time.
Normal dose of the VIDE treatment. Good effect of the nausea treatment with Emend/SoluMedrol.



March 27th, 2006

Diary Posted on 2006-12-15 09:32:18

Third round of chemo. Same as last, though the chemo-doses are decreased a little. This time she asks to try something else for her nausea. She is given Emend: 125 mg on the first day, 80 mg on second and third day, together with SoluMedrol: 160 mg on the first day, 80 mg on second and third day. This works REALLY well, and Mette is much better this time round, when she comes home.



March 15th, 2006

Diary Posted on 2006-12-15 09:27:51

Mette is hospitalised because she suddenly started running a fever. Antibiotics do the job, and she comes home again two days later.



March 9th, 2006

Diary Posted on 2006-12-15 09:24:12

End of second round of chemo. Mette is gradually being phased out of the OxyContin painkillers, as her general health is getting better. She is much better than after the first round of chemo.

Control scans show decrease in all tumors, so the treatment works very well!



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